Post-stroke angiotensin II type 2 receptor activation provides long-term neuroprotection in aged rats

Activation of the angiotensin II type 2 receptor (AT2R) by administration of Compound 21 (C21), a selective AT2R agonist, induces neuroprotection in models of ischemic stroke in young adult animals. The mechanisms of this neuroprotective action are varied, and may include direct and indirect effects...

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Udgivet i:PLoS One
Main Authors: Bennion, Douglas M., Isenberg, Jacob D., Harmel, Allison T., DeMars, Kelly, Dang, Alex N., Jones, Chad H., Pignataro, Megan E., Graham, Justin T., Steckelings, U. Muscha, Alexander, Jon C., Febo, Marcelo, Krause, Eric G., de Kloet, Annette D., Candelario-Jalil, Eduardo, Sumners, Colin
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495490/
https://ncbi.nlm.nih.gov/pubmed/28671997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180738
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