Post-stroke angiotensin II type 2 receptor activation provides long-term neuroprotection in aged rats

Activation of the angiotensin II type 2 receptor (AT2R) by administration of Compound 21 (C21), a selective AT2R agonist, induces neuroprotection in models of ischemic stroke in young adult animals. The mechanisms of this neuroprotective action are varied, and may include direct and indirect effects...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bennion, Douglas M., Isenberg, Jacob D., Harmel, Allison T., DeMars, Kelly, Dang, Alex N., Jones, Chad H., Pignataro, Megan E., Graham, Justin T., Steckelings, U. Muscha, Alexander, Jon C., Febo, Marcelo, Krause, Eric G., de Kloet, Annette D., Candelario-Jalil, Eduardo, Sumners, Colin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495490/
https://ncbi.nlm.nih.gov/pubmed/28671997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180738
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