Human genome-wide repair map of DNA damage caused by the cigarette smoke carcinogen benzo[a]pyrene

Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon, is the major cause of lung cancer. BaP forms covalent DNA adducts after metabolic activation and induces mutations. We have developed a method for capturing oligonucleotides carrying bulky base adducts, including UV-induced cyclobutane pyrimid...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Li, Wentao, Hu, Jinchuan, Adebali, Ogun, Adar, Sheera, Yang, Yanyan, Chiou, Yi-Ying, Sancar, Aziz
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495276/
https://ncbi.nlm.nih.gov/pubmed/28607059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706021114
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