Pharmacology of the Na(v)1.1 domain IV voltage sensor reveals coupling between inactivation gating processes

The Na(v)1.1 voltage-gated sodium channel is a critical contributor to excitability in the brain, where pathological loss of function leads to such disorders as epilepsy, Alzheimer’s disease, and autism. This voltage-gated sodium (Na(v)) channel subtype also plays an important role in mechanical pai...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Osteen, Jeremiah D., Sampson, Kevin, Iyer, Vivek, Julius, David, Bosmans, Frank
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495237/
https://ncbi.nlm.nih.gov/pubmed/28607094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621263114
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