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USP25 regulates Wnt signaling by controlling the stability of tankyrases
Aberrant activation of the Wnt signaling pathway plays an important role in human cancer development. Wnt signaling is negatively regulated by Axin, a scaffolding protein that controls a rate-limiting step in the destruction of β-catenin, the central activator of the Wnt pathway. In Wnt-stimulated c...
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| Publicado no: | Genes Dev |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5495119/ https://ncbi.nlm.nih.gov/pubmed/28619731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.300889.117 |
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