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Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: Modes of ligand binding and dimerization

In several species, GAF domains, which are widely expressed small-molecule-binding domains that regulate enzyme activity, are known to bind cyclic nucleotides. However, the molecular mechanism by which cyclic nucleotide binding affects enzyme activity is not known for any GAF domain. In the cyanobac...

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Bibliografiske detaljer
Main Authors: Martinez, Sergio E., Bruder, Sandra, Schultz, Anita, Zheng, Ning, Schultz, Joachim E., Beavo, Joseph A., Linder, Jürgen U.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC549502/
https://ncbi.nlm.nih.gov/pubmed/15708973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409913102
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