The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites

The tandem GAF domains from the cyanobacterium Anabaena PCC7120 cyaB2 adenylyl cyclase form an antiparallel dimer with cAMP bound to all four binding sites. cAMP binding causes highly cooperative allosteric enzyme activation (>500-fold; EC(50) = 1 μM; Hill coefficient >2.0). The cyaB2 GAF doma...

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Bibliographic Details
Main Authors: Bruder, Sandra, Linder, Jürgen U., Martinez, Sergio E., Zheng, Ning, Beavo, Joseph A., Schultz, Joachim E.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC549505/
https://ncbi.nlm.nih.gov/pubmed/15708972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409917102
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