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Linking E-cadherin mechanotransduction to cell metabolism through force mediated activation of AMPK
The response of cells to mechanical force is a major determinant of cell behavior and is an energetically costly event. How cells derive energy to resist mechanical force is unknown. Here, we show that application of force to E-cadherin stimulates Liver Kinase B1 (LKB1) to activate AMP-activated pro...
Shranjeno v:
| izdano v: | Nat Cell Biol |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5494977/ https://ncbi.nlm.nih.gov/pubmed/28553939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3537 |
| Oznake: |
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