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Positive selection of primate TRIM5α identifies a critical species-specific retroviral restriction domain
Primate genomes encode a variety of innate immune strategies to defend themselves against retroviruses. One of these, TRIM5α, can restrict diverse retroviruses in a species-specific manner. Thus, whereas rhesus TRIM5α can strongly restrict HIV-1, human TRIM5α only has weak HIV-1 restriction. The bio...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2005
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC549489/ https://ncbi.nlm.nih.gov/pubmed/15689398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409853102 |
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