BRCA1 and BRCA2 Germline Mutations are Frequently Demonstrated in Both High Risk Pancreatic Cancer Screening and Pancreatic Cancer Cohorts

BACKGROUND: Ten percent of pancreatic ductal adenocarcinoma (PDAC) is due to genetic predisposition, including the breast and ovarian cancer syndrome germline mutations BRCA1 and BRCA2. Knowledge of specific genetic mutations predisposing to PDAC may enable risk stratification, early detection and d...

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Publicado no:Cancer
Main Authors: Lucas, Aimee L., Frado, Laura, Hwang, Caroline, Kumar, Sheila, Khanna, Lauren G., Levinson, Elana, Chabot, John A., Chung, Wendy K., Frucht, Harold
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5494829/
https://ncbi.nlm.nih.gov/pubmed/24737347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28662
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