Accumulation of p53 protein is frequent in ovarian cancers associated with BRCA1 and BRCA2 germline mutations.

BACKGROUND: Mutations in the BRCA1 or BRCA2 genes are responsible for up to 95% of hereditary ovarian cancer cases. Both genes function as tumour suppressor genes, and development of a cancer is thought to require an accumulation of somatic genetic events in addition to the inherited germline predis...

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Detalhes bibliográficos
Main Authors: Zweemer, R P, Shaw, P A, Verheijen, R M, Ryan, A, Berchuck, A, Ponder, B A, Risch, H, McLaughlin, J R, Narod, S A, Menko, F H, Kenemans, P, Jacobs, I J
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1023075/
https://ncbi.nlm.nih.gov/pubmed/10560359
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