Prevalence and Penetrance of Germline BRCA1 and BRCA2 Mutations in a Population Series of 649 Women with Ovarian Cancer

A population-based series of 649 unselected incident cases of ovarian cancer diagnosed in Ontario, Canada, during 1995–96 was screened for germline mutations in BRCA1 and BRCA2. We specifically tested for 11 of the most commonly reported mutations in the two genes. Then, cases were assessed with the...

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Main Authors: Risch, Harvey A., McLaughlin, John R., Cole, David E. C., Rosen, Barry, Bradley, Linda, Kwan, Elaine, Jack, Elaine, Vesprini, Danny J., Kuperstein, Graciela, Abrahamson, John L. A., Fan, Isabel, Wong, Betty, Narod, Steven A.
Format: Artigo
Language:Inglês
Published: The American Society of Human Genetics 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1274482/
https://ncbi.nlm.nih.gov/pubmed/11179017
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