Variation of mutant allele frequency in NRAS Q61 mutated melanomas

BACKGROUND: Somatic mutations of BRAF or NRAS activating the MAP kinase cell signaling pathway are present in 70% of cutaneous melanomas. The mutant allele frequency of BRAF V600E (M%BRAF) was recently shown to be highly heterogeneous in melanomas. The present study focuses on the NRAS Q61 mutant al...

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Udgivet i:BMC Dermatol
Main Authors: Hélias-Rodzewicz, Zofia, Funck-Brentano, Elisa, Terrones, Nathalie, Beauchet, Alain, Zimmermann, Ute, Marin, Cristi, Saiag, Philippe, Emile, Jean-François
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5494128/
https://ncbi.nlm.nih.gov/pubmed/28668077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12895-017-0061-x
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