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Gly74Ser mutation in protein C causes thrombosis due to a defect in protein S-dependent anticoagulant function
Protein C is a vitamin K-dependent serine protease zymogen in plasma which upon activation by thrombin in complex with thrombomodulin (TM) down-regulates the clotting cascade by a feedback loop inhibition mechanism. Activated protein C (APC) exerts its anticoagulant function through protein S-depend...
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| Publicado no: | Thromb Haemost |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5493976/ https://ncbi.nlm.nih.gov/pubmed/28405673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH17-01-0043 |
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