Specific Inactivation and Nuclear Anchoring of Extracellular Signal-Regulated Kinase 2 by the Inducible Dual-Specificity Protein Phosphatase DUSP5

The mechanisms which determine the nuclear accumulation and inactivation of the extracellular signal-regulated kinase 1 (ERK1) or ERK2 mitogen-activated protein (MAP) kinases are poorly understood. Here we demonstrate that DUSP5, an inducible nuclear phosphatase, interacts specifically with ERK2 via...

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Bibliographic Details
Main Authors: Mandl, Margret, Slack, David N., Keyse, Stephen M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC549372/
https://ncbi.nlm.nih.gov/pubmed/15713638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.5.1830-1845.2005
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