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A Silenced Plasmodium falciparum var Promoter Can Be Activated In Vivo through Spontaneous Deletion of a Silencing Element in the Intron

Introns of Plasmodium falciparum var genes act as transcriptional silencing elements that help control antigenic variations. In transfected episomes, intron silencing of a drug-selectable marker under var promoter control is reversed by the spontaneous deletion of key intron regions. The resulting p...

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Detalhes bibliográficos
Main Authors: Gannoun-Zaki, Laïla, Jost, Amy, Mu, Jianbing, Deitsch, Kirk W., Wellems, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC549332/
https://ncbi.nlm.nih.gov/pubmed/15701812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.4.2.490-492.2005
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