CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for var2csa Gene Activation or Silencing in Plasmodium falciparum

Plasmodium falciparum relies on monoallelic expression of 1 of 60 var virulence genes for antigenic variation and host immune evasion. Each var gene contains a conserved intron which has been implicated in previous studies in both activation and repression of transcription via several epigenetic mec...

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Vydáno v:mBio
Hlavní autoři: Bryant, Jessica M., Regnault, Clément, Scheidig-Benatar, Christine, Baumgarten, Sebastian, Guizetti, Julien, Scherf, Artur
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513710/
https://ncbi.nlm.nih.gov/pubmed/28698275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00729-17
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