Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis

BACKGROUND: The importance of the mTOR complex 2 (mTORC2) signaling complex in tumor progression is becoming increasingly recognized. HER2-amplified breast cancers use Rictor/mTORC2 signaling to drive tumor formation, tumor cell survival and resistance to human epidermal growth factor receptor 2 (HE...

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Publicado en:Breast Cancer Res
Main Authors: Morrison Joly, Meghan, Williams, Michelle M., Hicks, Donna J., Jones, Bayley, Sanchez, Violeta, Young, Christian D., Sarbassov, Dos D., Muller, William J., Brantley-Sieders, Dana, Cook, Rebecca S.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5493112/
https://ncbi.nlm.nih.gov/pubmed/28666462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-017-0868-8
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