mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis

Akt phosphorylation is a major driver of cell survival, motility, and proliferation in development and disease, causing increased interest in upstream regulators of Akt like mTOR complex 2 (mTORC2). We used genetic disruption of Rictor to impair mTORC2 activity in mouse mammary epithelia, which decr...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Morrison, Meghan M., Young, Christian D., Wang, Shan, Sobolik, Tammy, Sanchez, Violeta M., Hicks, Donna J., Cook, Rebecca S., Brantley-Sieders, Dana M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4488502/
https://ncbi.nlm.nih.gov/pubmed/26132202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005291
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