Stimulation of Adenosine A(2B) Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway

Background and Purpose: Cardiac fibrosis is characterized by an increase in fibroblast proliferation, overproduction of extracellular matrix proteins, and the formation of myofibroblast that express α-smooth muscle actin (α-SMA). Endothelin-1 (ET-1) is involved in the pathogenesis of cardiac fibrosi...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Phosri, Sarawuth, Arieyawong, Ajaree, Bunrukchai, Kwanchai, Parichatikanond, Warisara, Nishimura, Akiyuki, Nishida, Motohiro, Mangmool, Supachoke
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492828/
https://ncbi.nlm.nih.gov/pubmed/28713274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00428
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