Synthesis and Antileishmanial Activities of Novel 3-Substituted Quinolines

The antileishmanial efficacy of four novel quinoline derivatives was determined in vitro against Leishmania chagasi, using extracellular and intracellular parasite models. When tested against L. chagasi-infected macrophages, compound 3b demonstrated 8.3-fold greater activity than did the standard pe...

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Hauptverfasser: Tempone, André Gustavo, Pompeu da Silva, Ana Cláudia Melo, Brandt, Carlos Alberto, Martinez, Fernanda Scalzaretto, Treiger Borborema, Samanta Etel, Barata da Silveira, Maria Amélia, de Andrade, Heitor Franco
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Susceptibility
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC549264/
https://ncbi.nlm.nih.gov/pubmed/15728905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.3.1076-1080.2005
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