Aryl hydrocarbon receptor inhibition promotes hematolymphoid development from human pluripotent stem cells

The aryl hydrocarbon receptor (AHR) plays an important physiological role in hematopoiesis. AHR is highly expressed in hematopoietic stem and progenitor cells (HSPCs) and inhibition of AHR results in a marked expansion of human umbilical cord blood–derived HSPCs following cytokine stimulation. It is...

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發表在:Blood
Main Authors: Angelos, Mathew G., Ruh, Paige N., Webber, Beau R., Blum, Robert H., Ryan, Caitlin D., Bendzick, Laura, Shim, Seonhui, Yingst, Ashley M., Tufa, Dejene M., Verneris, Michael R., Kaufman, Dan S.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2017
主題:
Hematopoiesis and Stem Cells
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492090/
https://ncbi.nlm.nih.gov/pubmed/28533309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-07-730440
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