Aryl hydrocarbon receptor inhibition promotes hematolymphoid development from human pluripotent stem cells

The aryl hydrocarbon receptor (AHR) plays an important physiological role in hematopoiesis. AHR is highly expressed in hematopoietic stem and progenitor cells (HSPCs) and inhibition of AHR results in a marked expansion of human umbilical cord blood–derived HSPCs following cytokine stimulation. It is...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Angelos, Mathew G., Ruh, Paige N., Webber, Beau R., Blum, Robert H., Ryan, Caitlin D., Bendzick, Laura, Shim, Seonhui, Yingst, Ashley M., Tufa, Dejene M., Verneris, Michael R., Kaufman, Dan S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492090/
https://ncbi.nlm.nih.gov/pubmed/28533309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-07-730440
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