Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF)

Primary cilia play central roles in signaling during metazoan development. Several key regulators of ciliogenesis and ciliary signaling are mutated in humans, resulting in a number of ciliopathies, including Joubert syndrome (JS). ARL13B is a ciliary GTPase with at least three missense mutations ide...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ivanova, Anna A., Caspary, Tamara, Seyfried, Nicholas T., Duong, Duc M., West, Andrew B., Liu, Zhiyong, Kahn, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491791/
https://ncbi.nlm.nih.gov/pubmed/28487361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.784025
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