Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption

Sepsis, during which the intestinal epithelial barrier is frequently disrupted, remains a challenging and life-threatening problem in clinical practice. The P2X7 receptor (P2X7R) is a non-selective adenosine triphosphate-gated cation channel present in macrophages that is involved in inflammatory re...

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Udgivet i:Sci Rep
Main Authors: Wu, Xiuwen, Ren, Jianan, Chen, Guopu, Wu, Lei, Song, Xian, Li, Guanwei, Deng, Youming, Wang, Gefei, Gu, Guosheng, Li, Jieshou
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491531/
https://ncbi.nlm.nih.gov/pubmed/28663567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04231-5
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