Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption

Sepsis, during which the intestinal epithelial barrier is frequently disrupted, remains a challenging and life-threatening problem in clinical practice. The P2X7 receptor (P2X7R) is a non-selective adenosine triphosphate-gated cation channel present in macrophages that is involved in inflammatory re...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Wu, Xiuwen, Ren, Jianan, Chen, Guopu, Wu, Lei, Song, Xian, Li, Guanwei, Deng, Youming, Wang, Gefei, Gu, Guosheng, Li, Jieshou
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491531/
https://ncbi.nlm.nih.gov/pubmed/28663567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04231-5
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