A Novel Inhibitor of Homeodomain Interacting Protein Kinase 2 Mitigates Kidney Fibrosis through Inhibition of the TGF-β1/Smad3 Pathway

Homeodomain interacting protein kinase 2 (HIPK2) is a critical regulator of multiple profibrotic pathways, including that of TGF-β1/Smad3. Genetic ablation of HIPK2 was shown previously to significantly reduce renal fibrosis in the experimental unilateral ureteral obstruction model and Tg26 mice, a...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Soc Nephrol
Prif Awduron: Liu, Ruijie, Das, Bhaskar, Xiao, Wenzhen, Li, Zhengzhe, Li, Huilin, Lee, Kyung, He, John Cijiang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Nephrology 2017
Pynciau:
Basic Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491283/
https://ncbi.nlm.nih.gov/pubmed/28220029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016080841
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