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Ultrasensitivity in signaling cascades revisited: Linking local and global ultrasensitivity estimations

Ultrasensitive response motifs, capable of converting graded stimuli into binary responses, are well-conserved in signal transduction networks. Although it has been shown that a cascade arrangement of multiple ultrasensitive modules can enhance the system’s ultrasensitivity, how a given combination...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Altszyler, Edgar, Ventura, Alejandra C., Colman-Lerner, Alejandro, Chernomoretz, Ariel
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491127/
https://ncbi.nlm.nih.gov/pubmed/28662096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180083
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