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Intratumoural production of TNFα by bacteria mediates cancer therapy

Systemic administration of the highly potent anticancer therapeutic, tumour necrosis factor alpha (TNFα) induces high levels of toxicity and is responsible for serious side effects. Consequently, tumour targeting is required in order to confine this toxicity within the locality of the tumour. Bacter...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Murphy, Carola, Rettedal, Elizabeth, Lehouritis, Panos, Devoy, Ciarán, Tangney, Mark
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491124/
https://ncbi.nlm.nih.gov/pubmed/28662099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180034
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