NK cell heparanase controls tumor invasion and immune surveillance

NK cells are highly efficient at preventing cancer metastasis but are infrequently found in the core of primary tumors. Here, have we demonstrated that freshly isolated mouse and human NK cells express low levels of the endo-β-D-glucuronidase heparanase that increase upon NK cell activation. Heparan...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Putz, Eva M., Mayfosh, Alyce J., Kos, Kevin, Barkauskas, Deborah S., Nakamura, Kyohei, Town, Liam, Goodall, Katharine J., Yee, Dean Y., Poon, Ivan K.H., Baschuk, Nikola, Souza-Fonseca-Guimaraes, Fernando, Hulett, Mark D., Smyth, Mark J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490772/
https://ncbi.nlm.nih.gov/pubmed/28581441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92958
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