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Soluble Heparan Sulfate Fragments Generated by Heparanase Trigger the Release of Pro-Inflammatory Cytokines through TLR-4

Heparanase is a β-D-endoglucuronidase that cleaves heparan sulfate (HS), facilitating degradation of the extracellular matrix (ECM) and the release of HS-bound biomolecules including cytokines. The remodeling of the ECM by heparanase is important for various physiological and pathological processes,...

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Autori principali: Goodall, Katharine J., Poon, Ivan K. H., Phipps, Simon, Hulett, Mark D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190175/
https://ncbi.nlm.nih.gov/pubmed/25295599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109596
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