Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4(+) T cells

HIV-1 causes a chronic, incurable disease due to its persistence in CD4(+) T cells that contain replication-competent provirus, but exhibit little or no active viral gene expression and effectively resist combination antiretroviral therapy (cART). These latently infected T cells represent an extreme...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Lee, Guinevere Q., Orlova-Fink, Nina, Einkauf, Kevin, Chowdhury, Fatema Z., Sun, Xiaoming, Harrington, Sean, Kuo, Hsiao-Hsuan, Hua, Stephane, Chen, Hsiao-Rong, Ouyang, Zhengyu, Reddy, Kavidha, Dong, Krista, Ndung’u, Thumbi, Walker, Bruce D., Rosenberg, Eric S., Yu, Xu G., Lichterfeld, Mathias
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490740/
https://ncbi.nlm.nih.gov/pubmed/28628034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI93289
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