Comparison of Direct Sequencing, Real-Time PCR-High Resolution Melt (PCR-HRM) and PCR-Restriction Fragment Length Polymorphism (PCR-RFLP) Analysis for Genotyping of Common Thiopurine Intolerant Variant Alleles NUDT15 c.415C>T and TPMT c.719A>G (TPMT*3C)

Thiopurine intolerance and treatment-related toxicity, such as fatal myelosuppression, is related to non-function genetic variants encoding thiopurine S-methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15). Genetic testing of the common variants NUDT15:NM_018283.2:c.415C>T (Arg139Cys, dbSNP r...

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Detaylı Bibliyografya
Yayımlandı:Diagnostics (Basel)
Asıl Yazarlar: Fong, Wai-Ying, Ho, Chi-Chun, Poon, Wing-Tat
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489947/
https://ncbi.nlm.nih.gov/pubmed/28498350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/diagnostics7020027
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