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Analysis of congenital hypomyelinating Egr2(Lo/Lo) nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination
Egr2 is a transcription factor required for peripheral nerve myelination in rodents, and mutations in Egr2 are associated with congenital hypomyelinating neuropathy (CHN) in humans. To further study its role in myelination, we generated mice harboring a hypomorphic Egr2 allele (Egr2(Lo)) that surviv...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC548989/ https://ncbi.nlm.nih.gov/pubmed/15695336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407836102 |
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