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Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development
Assembly of Ig genes in B lineage cells involves two distinct DNA rearrangements. In early B cell development, site-specific double strand breaks (DSBs) at germ-line V, D, and J gene segments are joined via nonhomologous end-joining (NHEJ) to form variable region exons. Activated mature B cells can...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2005
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC548986/ https://ncbi.nlm.nih.gov/pubmed/15699324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409857102 |
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