PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells

Ischemia/reperfusion injury triggers acute kidney injury (AKI) by aggravating oxidative stress mediated mitochondria dysfunction. The peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is a master player that regulates mitochondrial biogenesis and the antioxidant response. We p...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Choi, Hoon-In, Kim, Hye-Jin, Park, Jung-Sun, Kim, In-Jin, Bae, Eun Hui, Ma, Seong Kwon, Kim, Soo Wan
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489530/
https://ncbi.nlm.nih.gov/pubmed/28659586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04593-w
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