Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2

Matrix metalloproteinases (MMPs) are regulated at multiple transcriptional and post-transcriptional levels, among which receptor-mediated endocytic clearance. We previously showed that low-density lipoprotein receptor-related protein-1 (LRP-1) mediates the clearance of a complex between the zymogen...

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Pubblicato in:Sci Rep
Autori principali: Johanns, Manuel, Lemoine, Pascale, Janssens, Virginie, Grieco, Giuseppina, Moestrup, Soren K., Nielsen, Rikke, Christensen, Erik I., Courtoy, Pierre J., Emonard, Hervé, Marbaix, Etienne, Henriet, Patrick
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489529/
https://ncbi.nlm.nih.gov/pubmed/28659595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04648-y
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