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Sulfonyl fluorides as privileged warheads in chemical biology

Sulfonyl fluoride electrophiles have found significant utility as reactive probes in chemical biology and molecular pharmacology. As warheads they possess the right balance of biocompatibility (including aqueous stability) and protein reactivity. Their functionality is privileged in this regard as t...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Narayanan, Arjun, Jones, Lyn H.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489032/
https://ncbi.nlm.nih.gov/pubmed/28706662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc00408j
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