Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene

Oncogenic RAS mutations are present in 15–30% of thyroid carcinomas. Endogenous expression of mutant Ras is insufficient to initiate thyroid tumorigenesis in murine models, indicating that additional genetic alterations are required. We used Sleeping Beauty (SB) transposon mutagenesis to identify ev...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Montero-Conde, Cristina, Leandro-Garcia, Luis J., Chen, Xu, Oler, Gisele, Ruiz-Llorente, Sergio, Ryder, Mabel, Landa, Iñigo, Sanchez-Vega, Francisco, La, Konnor, Ghossein, Ronald A., Bajorin, Dean F., Knauf, Jeffrey A., Riordan, Jesse D., Dupuy, Adam J., Fagin, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488945/
https://ncbi.nlm.nih.gov/pubmed/28584132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702723114
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados