Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene

Oncogenic RAS mutations are present in 15–30% of thyroid carcinomas. Endogenous expression of mutant Ras is insufficient to initiate thyroid tumorigenesis in murine models, indicating that additional genetic alterations are required. We used Sleeping Beauty (SB) transposon mutagenesis to identify ev...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Montero-Conde, Cristina, Leandro-Garcia, Luis J., Chen, Xu, Oler, Gisele, Ruiz-Llorente, Sergio, Ryder, Mabel, Landa, Iñigo, Sanchez-Vega, Francisco, La, Konnor, Ghossein, Ronald A., Bajorin, Dean F., Knauf, Jeffrey A., Riordan, Jesse D., Dupuy, Adam J., Fagin, James A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488945/
https://ncbi.nlm.nih.gov/pubmed/28584132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702723114
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