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Crystal structure of tubulin tyrosine ligase-like 3 reveals essential architectural elements unique to tubulin monoglycylases

Glycylation and glutamylation, the posttranslational addition of glycines and glutamates to genetically encoded glutamates in the intrinsically disordered tubulin C-terminal tails, are crucial for the biogenesis and stability of cilia and flagella and play important roles in metazoan development. Me...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Garnham, Christopher P., Yu, Ian, Li, Yan, Roll-Mecak, Antonina
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488916/
https://ncbi.nlm.nih.gov/pubmed/28576883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617286114
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