DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs

The vertebrate-conserved RNA-binding protein (RBP) DND1 is required for survival of primordial germ cells (PGCs), as well as germ cell tumour (TGCT) suppression in mice(1–5). Here we report that DND1 binds a UU[A/U] trinucleotide motif predominantly in messenger RNA (mRNA) 3′ untranslated regions (U...

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Vydáno v:Nature
Hlavní autoři: Yamaji, Masashi, Jishage, Miki, Meyer, Cindy, Suryawanshi, Hemant, Der, Evan, Yamaji, Misaki, Garzia, Aitor, Morozov, Pavel, Manickavel, Sudhir, McFarland, Hannah L., Roeder, Robert G., Hafner, Markus, Tuschl, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488729/
https://ncbi.nlm.nih.gov/pubmed/28297718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21690
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