miR-16 rescues F508del-CFTR function in native cystic fibrosis epithelial cells

Cystic fibrosis (CF) is due to mutations in the CFTR gene, which prevents correct folding, trafficking and function of the mutant cystic fibrosis transmembrane conductance regulator (CFTR) protein. The dysfunctional effect of CFTR mutations, principally the F508del-CFTR mutant, is further manifested...

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Detalhes bibliográficos
Publicado no:Gene Ther
Main Authors: Kumar, P, Bhattacharyya, S, Peters, KW, Glover, ML, Sen, A, Cox, RT, Kundu, S, Caohuy, H, Frizzell, RA, Pollard, HB, Biswas, R
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488273/
https://ncbi.nlm.nih.gov/pubmed/26133785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2015.56
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