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Arrhythmic effects of Epac‐mediated ryanodine receptor activation in Langendorff‐perfused murine hearts are associated with reduced conduction velocity

Recent papers have attributed arrhythmic substrate in murine RyR2‐P2328S hearts to reduced action potential (AP) conduction velocities (CV), reflecting acute functional inhibition and/or reduced expression of sodium channels. We explored for acute effects of direct exchange protein directly activate...

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Publicado en:Clin Exp Pharmacol Physiol
Autores principales: Li, Mengye, Hothi, Sandeep S, Salvage, Samantha C, Jeevaratnam, Kamalan, Grace, Andrew A, Huang, Christopher L‐H
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488224/
https://ncbi.nlm.nih.gov/pubmed/28316073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/1440-1681.12751
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