Epac‐induced ryanodine receptor type 2 activation inhibits sodium currents in atrial and ventricular murine cardiomyocytes

Acute RyR2 activation by exchange protein directly activated by cAMP (Epac) reversibly perturbs myocyte Ca(2+) homeostasis, slows myocardial action potential conduction, and exerts pro‐arrhythmic effects. Loose patch‐clamp studies, preserving in vivo extracellular and intracellular conditions, inves...

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Vydáno v:Clin Exp Pharmacol Physiol
Hlavní autoři: Valli, Haseeb, Ahmad, Shiraz, Sriharan, Sujan, Dean, Lydia D, Grace, Andrew A, Jeevaratnam, Kamalan, Matthews, Hugh R, Huang, Christopher L‐H
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814738/
https://ncbi.nlm.nih.gov/pubmed/29027245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/1440-1681.12870
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