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Identification of Antifungal H(+)-ATPase Inhibitors with Effect on Plasma Membrane Potential

The plasma membrane H(+)-ATPase (Pma1) is an essential fungal protein and a proposed target for new antifungal medications. The compounds in a small-molecule library containing ∼191,000 commercially available compounds were screened for their ability to inhibit Saccharomyces cerevisiae plasma membra...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Kjellerup, Lasse, Gordon, Sandra, Cohrt, Karen O'Hanlon, Brown, William Dalby, Fuglsang, Anja Thoe, Winther, Anne-Marie L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487681/
https://ncbi.nlm.nih.gov/pubmed/28438931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00032-17
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