Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity

We have identified a series of tetrahydrocarbazoles as novel P-type ATPase inhibitors. Using a set of rationally designed analogues, we have analyzed their structure-activity relationship using functional assays, crystallographic data and computational modeling. We found that tetrahydrocarbazoles in...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bublitz, Maike, Kjellerup, Lasse, Cohrt, Karen O’Hanlon, Gordon, Sandra, Mortensen, Anne Louise, Clausen, Johannes D., Pallin, Thomas David, Hansen, John Bondo, Fuglsang, Anja Thoe, Dalby-Brown, William, Winther, Anne-Marie L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749684/
https://ncbi.nlm.nih.gov/pubmed/29293507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188620
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