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Terbinafine Resistance of Trichophyton Clinical Isolates Caused by Specific Point Mutations in the Squalene Epoxidase Gene

Terbinafine is one of the allylamine antifungal agents whose target is squalene epoxidase (SQLE). This agent has been extensively used in the therapy of dermatophyte infections. The incidence of patients with tinea pedis or unguium tolerant to terbinafine treatment prompted us to screen the terbinaf...

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Publicado en:Antimicrob Agents Chemother
Main Authors: Yamada, Tsuyoshi, Maeda, Mari, Alshahni, Mohamed Mahdi, Tanaka, Reiko, Yaguchi, Takashi, Bontems, Olympia, Salamin, Karine, Fratti, Marina, Monod, Michel
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487658/
https://ncbi.nlm.nih.gov/pubmed/28416557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00115-17
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