Terbinafine Resistance of Trichophyton Clinical Isolates Caused by Specific Point Mutations in the Squalene Epoxidase Gene

Terbinafine is one of the allylamine antifungal agents whose target is squalene epoxidase (SQLE). This agent has been extensively used in the therapy of dermatophyte infections. The incidence of patients with tinea pedis or unguium tolerant to terbinafine treatment prompted us to screen the terbinaf...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Yamada, Tsuyoshi, Maeda, Mari, Alshahni, Mohamed Mahdi, Tanaka, Reiko, Yaguchi, Takashi, Bontems, Olympia, Salamin, Karine, Fratti, Marina, Monod, Michel
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487658/
https://ncbi.nlm.nih.gov/pubmed/28416557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00115-17
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