Efficacy of Ceftaroline against Methicillin-Susceptible Staphylococcus aureus Exhibiting the Cefazolin High-Inoculum Effect in a Rat Model of Endocarditis

Certain Staphylococcus aureus strains exhibit an inoculum effect (InE) with cefazolin (CFZ) that has been associated with therapeutic failures in high-inoculum infections. We assessed the in vitro activities of ceftaroline (CPT), CFZ, and nafcillin (NAF) against 17 type A β-lactamase (βla)-producing...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Singh, Kavindra V., Tran, Truc T., Nannini, Esteban C., Tam, Vincent H., Arias, Cesar A., Murray, Barbara E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487651/
https://ncbi.nlm.nih.gov/pubmed/28483961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00324-17
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