Mutations in the Transmembrane Domain and Cytoplasmic Tail of Hendra Virus Fusion Protein Disrupt Virus-Like-Particle Assembly

Hendra virus (HeV) is a zoonotic paramyxovirus that causes deadly illness in horses and humans. An intriguing feature of HeV is the utilization of endosomal protease for activation of the viral fusion protein (F). Here we investigated how endosomal F trafficking affects HeV assembly. We found that t...

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Bibliographic Details
Published in:J Virol
Main Authors: Cifuentes-Muñoz, Nicolás, Sun, Weina, Ray, Greeshma, Schmitt, Phuong Tieu, Webb, Stacy, Gibson, Kathleen, Dutch, Rebecca Ellis, Schmitt, Anthony P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487568/
https://ncbi.nlm.nih.gov/pubmed/28468881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00152-17
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